Early Gastrointestinal Cancers: 196 (Recent Results in Cancer Research)

Second Malignant Neoplasms in Operable Carcinoma of the Breast
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Share Give access Share full text access. Share full text access. Please review our Terms and Conditions of Use and check box below to share full-text version of article. Methods We conducted a cohort study within the membership of the Kaiser Permanente Northern California healthcare system and compared rates of gastric and other cancers among pantoprazole users and users of other PPI medications.

Participants Two treatment groups were compared. Figure 1 Open in figure viewer PowerPoint. Exposure variables Medication exposure data were obtained from the KPNC prescription database and all definitions were defined a priori. Outcomes The primary outcome was gastric cancer; secondary endpoints included colon cancer, liver cancer, cancer of the small intestine and pancreatic cancer.

Confounding and effect modification Covariates were collected at index date i. Sensitivity analyses We conducted several exploratory analyses that varied censoring criteria and the primary risk window. Results We identified 61 persons who met exposure criteria for inclusion in the study. Additional censoring is evaluated in models for each specific cancer. Gastric cancer endpoints The overall risk of gastric cancer was similar between the pantoprazole and other PPI groups in both unadjusted HR: 0.

Excludes cancers diagnosed within the first year after the index date. Any cancer endpoint The unadjusted incidence rates for any cancer excluding nonmelanoma skin cancers in the pantoprazole group were Authorship Guarantor of the article : Douglas Corley. All authors approved the final version of the manuscript. Acknowledgement Declaration of personal interests : Douglas Corley and Jennifer Schneider are employees of Kaiser Permanente Northern California, who were paid consultants to Pfizer in connection with the development of this manuscript. Declaration of funding interests : This study was funded in full by Pfizer.

Figure S1. Distribution of index exposures over calendar time, by exposure group. Toxicol Pathol ; 16 : — Citing Literature. Volume 43 , Issue 1 January Pages Figures References Related Information.

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An increase in most types of cancer was observed during the study period. The latest results of the East Azerbaijan Population-Based Cancer The first estimates of the incidence of cancer in East Azerbaijan In both sexes, gastrointestinal cancers were among the top five most .. ;15(4)– Since miR are consistently found over-expressed in digestive tract cancer tissues, Over the past decade, the emergence of miRNA research has firmly Here, we review recent reports on miR family molecules in cancer, whose which results in to nt precursor miRNAs (pre-miRNAs).

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Request Username Can't sign in? Forgot your username? Enter your email address below and we will send you your username. Rate ratio age—sex adjusted c c Adjusted for age at index date. Grant funding agencies and grant reviewers most of whom may not have had any experience in rare cancer research face a major problem in judging the quality of rare cancer research proposals.

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Surgery a gastrectomy and radiation therapy are considered local treatments. Randomized trial of short-course radiotherapy versus long-course chemoradiation comparing rates of local recurrence in patients with T3 rectal cancer: Trans-Tasman Radiation Oncology Group trial Exposure of cells to an exogenous NO donor or increased expression of NOS2 leads to accumulation of p53 protein 45 , 62 , Cancer survivorship is a relatively new focus of oncology care. Studies conducted in the early s with samples from patients suffering from IBD showed increased activity of NOS2 12 , levels of its substrate, l -arginine, and product, citrulline in UC, Furthermore, NOS2 expression was associated with increased metastasis and angiogenesis in patients with gastric cancer

Indeed, it is expected that such applications should contain all the components that make a successful application in the common cancer paradigm: adequate sample calculations for biomarker discovery and validation, preliminary in vitro evidence of the research question, cell lines and animal models to test the research hypothesis, adequately designed and powered clinical trials and so on.

While some of these shortcomings can be tackled with international consortia, others are very difficult if not possible to address in the space of rare cancer research. Figure 1 depicts the 2 main models of research design when interrogating cancer samples.

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This is then confirmed with analysis of clinical samples, either directly or via xenograft models, and the confirmation of the clinical relevance of those findings informs a possible clinical trial. Schematic paths for research design in the context of translational research in cancer. In either model, we have highlighted in blue the activities that may need to be revisited i. In either model, we have highlighted in blue the portions that become significantly challenged when undertaking research in rare cancer.

Similarly, patient derived xenografts seem to be essential for the monitoring of cancer dynamics and complexity Aparicio et al, However, we know that, in rare cancers, generating these resources in sufficient numbers or variety to make them meaningful will be an extremely difficult, if not impossible, task. The characterisation of large cohorts of clinical samples to power biomarker discovery studies in rare cancers is another difficult task, which can be in part mitigated by large, multi-national consortia.

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The problem here is that samples coming from multiple centres, from a disease that often does not have a nationally or internationally agreed standard of care, typically leads to samples with diverse therapeutic interventions and pathology curation, thus lacking the relative homogeneity of large cohorts of common cancers.

This, together with the lack of existing clinical trials in rare cancers that could be informed by the results of genetic studies, makes the overall landscape of research programme argumentation difficult and frustrating. In theory, the scientific community should not water down the definition of good research because of aspects that are operational rather than conceptual. At the same time, we should not judge scientific proposals and scientific merit in rare cancer studies in the same way as we do for mainstream malignancies, as this may not only be scientifically flawed, but may also represent a strategic mistake that will deny therapeutic advancement to almost a quarter of all cancer patients.

BJC : — Oncotarget 6 : — Nat Rev Cancer 15 : — Eur J Cancer 51 3 : — In either model, we have highlighted in blue the portions that become significantly challenged when undertaking research in rare cancer. Similarly, patient derived xenografts seem to be essential for the monitoring of cancer dynamics and complexity Aparicio et al, However, we know that, in rare cancers, generating these resources in sufficient numbers or variety to make them meaningful will be an extremely difficult, if not impossible, task.

The characterisation of large cohorts of clinical samples to power biomarker discovery studies in rare cancers is another difficult task, which can be in part mitigated by large, multi-national consortia. The problem here is that samples coming from multiple centres, from a disease that often does not have a nationally or internationally agreed standard of care, typically leads to samples with diverse therapeutic interventions and pathology curation, thus lacking the relative homogeneity of large cohorts of common cancers.

Journal of Gastroenterology and Hepatology Research

This, together with the lack of existing clinical trials in rare cancers that could be informed by the results of genetic studies, makes the overall landscape of research programme argumentation difficult and frustrating. In theory, the scientific community should not water down the definition of good research because of aspects that are operational rather than conceptual. At the same time, we should not judge scientific proposals and scientific merit in rare cancer studies in the same way as we do for mainstream malignancies, as this may not only be scientifically flawed, but may also represent a strategic mistake that will deny therapeutic advancement to almost a quarter of all cancer patients.

BJC : — Oncotarget 6 : — Nat Rev Cancer 15 : — Eur J Cancer 51 3 : — J Natl Cancer Inst 7 : — Public Health Rep : 28— J Clin Oncol 31 36 : — N Engl J Med : — J Natl Cancer Inst. Ann Surg : — Science : 56—

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